PermeGear, Inc. manufactures Franz Cells, Horizontal Cells like the Crown Glass Side-Bi-Side cells, and related equipment for studying membrane transport and drug diffusion through biological and synthetic membranes. Applications include experimentation in the areas of drug discovery, drug transport, drug screening, controlled release, formulation optimization, dermatology, skin toxicology, oral absorption, buccal absorption, percutaneous absorption, equilibrium dialysis and protein binding. The most popular application is in the development of transdermal and topical pharmaceuticals. However, our equipment is also used in basic research or preformulation projects requiring measurement of diffusion coefficients, partition coefficients, and membrane permeabilities. We provide both specialized diffusion cells for research projects, such as iontophoresis, and automatic sampling systems for high-output measurements, such as in vitro release from topical pharmaceuticals.

Previously known as AMIE Systems, PermeGear manufactured Bronaugh Cells, Drive Consoles, and other apparatus for Crown Glass Company, Crown BioScientific (or Crown Scientific) until 1994. We still manufacture some of those products as well as our own innovative diffusion equipment like the In-Line Cell. We now blow our own glass cells which are identical to the classic Franz cell and Crown Glass Side-Bi-Side cell.

Recognizing these concerns, PermeGear is developing products and services to enable customers to economically automate labor-intensive experimental procedures. Our strategy is to rigorously investigate and thoroughly understand the problem and implement the most effective solution by integrating our products with third-party and in-house resources.